Prof. Dr. Talip ASİL

A1. Asil, T., Uzunca, I., Utku, U. and U. Berberoglu, “Monitoring Of İncreased İntracranial Pressure Resulting From Cerebral Edema with Transcranial Doppler Sonography İn Patients With Middle Cerebral Artery İnfarction,” J Ultrasound Med., 22, 1049-1053 (2003).

A2. Kilincer, C., Asil, T., Utku, U., Hamamcioglu, M.K., Turgut, N., Hicdönmez, T., Simsek, O., Ekuklu, G. and S. Cobanoglu, “Factors Affecting the Outcome of Decompressive Craniectomy for Large Hemispheric İnfarctions: A Prospective Cohort Study,” Acta Neurochir. (Wien), 147,587-594 (2005).

A3. Celik, Y., Utku, U., Asil, T. and K. Balci, “Factors Affecting Haemorrhagic Transformation in Middle Cerebral Artery İnfarctions,” J. Clin. Neurosci., 11, 656-658 (2004).

A4. Balci, K., Asil, T., Kerimoglu, M., Celik, Y. and U. Utku, “Clinical and Neuroradiological Predictors of Mortality in Patients with Primary Pontine Hemorrhage,” Clin. Neurol. Neurosurg., 108, 36-39 (2005).

A5. Unlu, E., Cakir, B. and T. Asil, “MRI Findings of Wernicke Encephalopathy Revisited Due to Hunger Strike,” Eur. J. Radiol., 57, 43-53 (2006).

A6. Uzuner, N., Ak, I., Gucuyener, D., Asil, T., Vardareli, E. and G. Ozdemir, “Cerebral Hemodynamic Patterns With Technetium Tc 99m Exametazime Single Photon Emission Computed Tomography And Transcranial Doppler Sonography: A Validation Study Using Visual Stimulation,” J. Ultrasound Med., 21, 955-959 (2002).

A7. Asil, T. and N. Uzuner, “Differentiation of Vascular Dementia and Alzheimer Disease: A Functional Transcranial Doppler Ultrasonographic Study,” J. Ultrasound Med., 24, 1065-1070 (2005).

A8. Utku, U., Asil, T., Celik, Y. and D, Tucer, “Reversible MR Angiographic Findings in a Patient with Autoimmune Graves Disease,” Am. J. Neuroradiol., 25, 1541-1543 (2004).

A9. Uzunca, I., Utku, U., Asil, T. and Y. Celik, “Fou Rire Prodromique Associated with Simultaneous Bilateral Capsular Genu İnfarction,” J. Clin. Neurosci., 12, 174-175 (2005).

A10. Utku, U., Asil, T., Balci, K., Uzunca, İ. and Y. Celik, “Hepatic Myelopathy with Spastic Papaparesis,” Clin. Neurol. Neurosurg., 107, 514-516 (2005).

A11. Asil, T., Utku, U., Balci, K. and C. Kilincer, “Recovery from Aphasia After Decompressive Surgery in Patients with Dominant Hemispheric İnfarction,” Stroke, 36, 2071 (2005).

A12. Umit, H., Asil, T., Celik, Y., Tezel, A., Dokmeci, G., Tuncbilek, N., Utku, U. and A.R. Soylu, “Cerebral Sinus Thrombosis in Patients with İnflammatory Bowel Disease: A Case Report,” World J. Gastroenterol., 11, 5404-5407 (2005).

A13. Gücüyener, D., Asil, T., Uzuner, N., Özkan, S. and G. Özdemir, “The Evaluation of Cerebral Oxygenation by Oximetry in Patients with İschemic Stroke,” J. Postgrad. Med., 46, 70-74 (2000).

A14. Celik, Y., Asil, T., Utku, U. and O. Birgili, “Orthostatic Hypotension Due To Bilateral Brainstem İnfarction,” The Int. Jıournal of Neurol.

A15. Asil, T., Balci, K., Uzunca, I., Kerimoglu, M. and U. Utku, “Six Months Follow up Study in Patients with Symptomatic Intracranial Stenosis,” J. Clin. Neurosci., 13, 913-16 (2006).

A16. Balci, K., Utku, U., Asil, T., N. Buyukkoyuncu, “Bilateral Thalamic and Basal Ganglionic Lesions due to Deep Cerebral Vein Thrombosis,” J. Clin. Neurosci., 14, 181-84 (2007).

A17. Asil, T., Utku, U., Unlu., E. and K. Balci, “Joubert Sydrome Associated with Total Corpus Callosum Agenesis”, Rivista di Neuroradiologia, 19, 75-79 (2006).

A18.  Asil, T., Balci, K., Uzunca, I., Kerimoglu M. and U. Utku. “Six-month follow-up study in patients with symptomatic intracranial arterial stenosis.” J. Clin. Neurosci., 13,913-6 (2006)

A19.  Asil,T., Utku, U., Balci, K. and I. Uzunca “Changing cerebral blood flow velocity by transcranial Doppler during head up tilt in patients with diabetes mellitus.” Clin. Neurol. Neurosurg. 26, 179-85 (2007)

A20.  Uzunca, I., Asil, T., Balci, K. and U. Utku. “Evaluation of vasomotor reactivity by transcranial Doppler sonography in patients with acute stroke who have symptomatic intracranial and extracranial stenosis.” J. Ultrasound Med. 26,179-85. (2007)

A21.  San, H., Tas, A., Uzun, C., Asil, T., Yagiz, R., and A.R. Karasalihoglu. “Assessment of patients with sudden hearing loss by transcranial Doppler ultrasonography.” Kulak Burun Bogaz Ihtis. Derg. 16,169-72 (2006).

A22. Celik Y, Temizoz O, Genchellac H, Cakir B, Asil T. A non-alcoholic patient with acute Marchiafava-Bignami disease associated with gynecologic malignancy: paraneoplastic Marchiafava-Bignami disease? Clin Neurol Neurosurg. 2007 Jul;109(6):505-8.

A23. Balci K, Utku U, Asil T, Unlu E Simultaneous onset of hemorrhagic and ischemic strokes. Neurologist. 2007 May;13(3):148-9.

A24. Kilinçer C, Asil T, Utku U, Balci K, Hamamcioglu MK. Decompression craniotomy. J Neurosurg. 2007 Dec;107(6):1276-7

A25. Gonul M, Asil T, Balci K, Celik Y, Turgut N, Uzunca I. Changing cerebral blood flow velocity detected by transcranial Doppler ultrasound during head up tilt in patients with multiple sclerosis. Eur J Neurol. 2008 Jul;15(7):725-9.

A26. Temizoz O, Celik Y, Asil T, Balci K, Unlu E, Yilmaz A Stroke due to bee sting. Neurologist. 2009 Jan;15(1):42-3.

A27. Asil T, Steffenhagen N, Ibrahim M, Demchuk A. Bubble study in patients with massive right-to-left shunt and recurrent stroke. Stroke. 2009 Jul;40(7)

A28 Asil T, Celik Y, Sut N, Celik AD, Balci K, Yilmaz A, Karaduman F. Cost of acute ischemic and hemorrhagic stroke in Turkey. Clin Neurol Neurosurg. 2011 Feb;113(2):111-4.

A29. Balci K, Utku U, Asil T, Celik Y. Ischemic stroke in young adults: risk factors, subtypes, and prognosis. Neurologist. 2011 Jan;17(1):16-20.

A30. Balci K, Asil T, Tekinaslan I, Ir N. Does cervical radiculopathy have an effect on peripheral nerve conduction studies? An electrophysiological evaluation. Eur Neurol. 2011;66(1):53-8

A31. Oztora S, Korkmaz O, Dagdeviren N, Celik Y, Caylan A, Top MS, Asil T. Migraine headaches among university students using ID Migraine test as a screening tool. BMC Neurol. 2011 Aug 19;11:103.

A32. Balci K, Utku U, Asil T, Celik Y, Tekinaslan I, Ir N, Unlu E. The effect of admission blood pressure on the prognosis of patients with intracerebral hemorrhage that occurred during treatment with aspirin, warfarin, or no drugs. Clin Exp Hypertens. 2012;34(2):118-24.

A33. Asil T, Ir N, Karaduman F, Cagli B, Tuncel S. Combined antithrombotic treatment with aspirin and clopidogrel for patients with capsular warning syndrome: a case report. Neurologist. 2012 Mar;18(2):68-9

A34.  Demchuk AM, Dowlatshahi D, Rodriguez-Luna D, Molina CA, Blas YS, Dzialowski I, Kobayashi A, Boulanger JM, Lum C, Gubitz G, Padma V, Roy J, Kase CS, Kosior J, Bhatia R, Tymchuk S, Subramaniam S, Gladstone DJ, Hill MD, Aviv RI; PREDICT/Sunnybrook ICH CTA study group. Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study. Lancet Neurol. 2012 Apr;11(4):307-14.

A35. Gürsoy AE, Babacan-Yıldız G, Kolukısa M, Asil T, Ertaş M. Neuromuscular transmission impairment in transient global amnesia. Neurol Sci. 2013 Oct;34(10):1835-6.

A36. Kocaman G, Eryigit G, Abbink TE, Kılıcarslan R, Asil T, Alkan A, Van der Knaap MS, Kocer A. An unusually mild presentation of megalencephalic leukoencephalopathy with subcortical cysts. Clin Neurol Neurosurg. 2013 Aug;115(8):1564

A 37 Ozcan ME, Altınöz MA, Karadeli HH, Asil T, Koçer A. 17-year-old female with systemic lupus presents with complex movement disorder: possible relationship with antiribosomal p antibodies  Case Rep Neurol Med. 2013;2013:590729.

A38. Tasal A, Asil T, Goktekin O.  Combined use of invatec mo.ma proximal protection device and Solitaire AB retrievable stent for tandem occlusions in a patient with acute ischemic stroke. J Invasive Cardiol. 2013 Oct;25(10):E194-7.

A39 Tasal A, Bacaksız A, Vatankulu MA, Asil T, Göktekin O. Endovascular therapy of acute ischemic stroke by interventional cardiologists: initial national experience. Turk Kardiyol Dern Ars. 2013 Dec;41(8):683-90

A40 Gürsoy AE, Kolukısa M, Babacan-Yıldız G, Altıntaş Ö, Yaman A, Asil T. Reversible conduction failure in overlap of Miller Fisher syndrome and pharyngeal-cervical-brachial variant of Guillain-Barré syndrome in the spectrum of nodo-paranodopathies. J Clin Neurosci. 2014 Jul;21(7):1269-71.

A41 Saygın Gülbahar D, Huseyin Karadeli H, Esenkaya Ö, Emin Ozcan M, Halac G, Asil T. Influences of socio-demographics on depression and anxiety in patients with complex partial and tonic-clonic seizures. Med Glas (Zenica). 2014 Aug;11(2):356-60.

A42 Ince B, Benbir G, Siva A, Saip S, Utku U, Celik Y, Necioglu-Orken D, Ozturk S, Afsar N, Aktan S, Asil T, Bakac G, Ekmekci H, Gokce M, Krespi Y, Midi I, Varlibas F, Citci-Yalcinkaya B, Goksan B, Uluduz D, Uyguner O. Clinical and radiological features in CADASIL and NOTCH3-negative patients: a multicenter study from Turkey. Eur Neurol. 2014;72(3-4):125-31

A43. Ozcan ME, Ince B, Karadeli HH, Asil T. Multiple sclerosis presents with psychotic symptoms and coexists with hypertrophic cardiomyopathy. Case Rep Neurol Med. 2014;2014:383108

A44. Altıntaş O, Gürsoy AE, Baran G, Mehdi E, Asil T. Bilateral jugular vein and sigmoid sinus thrombosis related to an inherited coagulopathy: an unusual presentation. Case Rep Vasc Med. 2014;2014:873402

A45. Ozcan ME, Ince B, Bingöl A, Ertürk S, Altınöz MA, Karadeli HH, Koçer A, Asil T. Association between smoking and cognitive impairment in multiple sclerosis. Neuropsychiatr Dis Treat. 2014 Sep 10;10:1715-9

A46. Goktekin O, Tasal A, Uyarel H, Vatankulu MA, Sonmez O, Kul S, Ay N, Yamac H, Altintas O, Karadeli H, Kolukisa M, Aralasmak A, Asil T. Endovascular therapy of acute ischaemic stroke by interventional cardiologists: single-centre experience from Turkey. EuroIntervention. 2014 Nov;10(7):876-83.

A47. Kolukısa M, Ozdemir Gültekin T, Eryigit Baran G, Aralasmak A, Kocaman G, Gürsoy AE, Asil T. Kolukısa M, Ozdemir Gültekin T, Eryigit Baran G, Aralasmak A, Kocaman G, Gürsoy AE, Asil T. Neuropsychiatr Dis Treat. 2015 Feb 18;11:379-84.

A48.  Aralasmak A, Atay M, Toprak H, Ozdemir T, Asil T, Goktekin O, Mehdi E, Ozdemir H, Alkan A.  Hyperperfusion in carotid stenting patients. J Comput Assist Tomogr. 2015 May-Jun;39(3):313-6

A49. Halac G, Demir S, Yucel H, Niftaliyev E, Kocaman G, Duruyen H, Kendirli T, Asil T. Splinting is effective for night-only symptomatic carpal tunnel syndrome patients. J Phys Ther Sci. 2015 Apr;27(4):993-6.

A50. Bilgiç B, Kocaman G, Arslan AB, Noyan H, Sherifov R, Alkan A, Asil T, Parman Y, Baykan B. Volumetric differences suggest involvement of cerebellum and brainstem in chronic migraine. Cephalalgia. 2016 Apr;36(4):301-8.

A51. Kolukısa M, Gürsoy AE, Kocaman G, Dürüyen H, Toprak H, Asil T. Carotid Endarterectomy in a Patient with Posterior Cerebral Artery Infarction: Influence of Fetal Type PCA on Atypical Clinical Course. Case Rep Neurol Med. 2015;2015:191202.

A52. Widimsky P, Asil T, Abelson M, Koznar B, Tasal A, Roos J, Vasko P, Peisker T, Deniz C, Vavrova J, Yamac HA, Stetkarova I, Bacaksiz A, Ay NK, Tuzgen S, Maly M, Goktekin O. Direct Catheter-Based Thrombectomy for Acute Ischemic Stroke: Outcomes of Consecutive Patients Treated in Interventional Cardiology Centers in Close Cooperation With Neurologists. J Am Coll Cardiol. 2015 Jul 28;66(4):487-8.

A53. Halac G, Topaloglu P, Demir S, Cıkrıkcıoglu MA, Karadeli HH, Ozcan ME, Asil T. Ulnar nerve entrapment neuropathy at the elbow: relationship between the electrophysiological findings and neuropathic pain. J Phys Ther Sci. 2015 Jul;27(7):2213-6

A54 Çelik Y, Tekataş A, Albayram S, Gündüz A, Asil T, Ünlü E, Özlece Köse H. Spontaneous intracranial hypotension presenting with coma: a case report and literature review. Agri. 2015;27(3):160-2.

A55 Altintas O, Antar V, Baran O, Karatas E, Altintas MO, Kesgin S, Buyukpinarbasili N, Kocyigit A, Asil T. Neuroprotective effects of hemicraniectomy in malign middle cerebral artery infarctions: experimental study. J Neurosurg Sci. 2015 Oct 6.

A56. Halac G, Sezer GM, Saglam NO, Tekturk P, Demir AD, Demir S, Akcay F, Uslu A, Yapıcı Z, Asil T. The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey. Neurosciences (Riyadh). 2015 Oct;20(4):336-40.

A57. Gürsoy AE, Bilgen HR, Dürüyen H, Altıntaş Ö, Kolukisa M, Asil T. Ulnar nerve entrapment neuropathy at the elbow: relationship between the electrophysiological findings and neuropathic pain. J Phys Ther Sci. 2015 Jul;27(7):2213-6.

A58. Çelik Y, Tekataş A, Albayram S, Gündüz A, Asil T, Ünlü E, Özlece Köse H. Spontaneous intracranial hypotension presenting with coma: a case report and literature review. Agri. 2015;27(3):160-2

A59. Altintas O, Antar V, Baran O, Karatas E, Altintas MO, Kesgin S, Buyukpinarbasili N, Kocyigit A, Asil T. Neuroprotective effects of hemicraniectomy in malign middle cerebral artery infarctions: experimental study. J Neurosurg Sci. 2015 Oct 6

A60 Halac G, Sezer GM, Saglam NO, Tekturk P, Demir AD, Demir S, Akcay F, Uslu A, Yapıcı Z, Asil T. The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey. Neurosciences (Riyadh). 2015 Oct;20(4):336-40

A61. Gürsoy AE, Bilgen HR, Dürüyen H, Altıntaş Ö, Kolukisa M, Asil T. The evaluation of vitamin D levels in patients with carpal tunnel syndrome.. Neurol Sci. 2016 Jul;37(7):1055-61

A62. Johnston SC, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KS; SOCRATES Steering Committee and Investigators. Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack. N Engl J Med. 2016 Jul 7;375(1):35-43.

A63. Rodriguez-Luna D, Coscojuela P, Rubiera M, Hill MD, Dowlatshahi D, Aviv RI, Silva Y, Dzialowski I, Lum C, Czlonkowska A, Boulanger JM, Kase CS, Gubitz G, Bhatia R, Padma V, Roy J, Tomasello A, Demchuk AM, Molina CA; PREDICT/Sunnybrook ICH CTA Study Group. Ultraearly hematoma growth in active intracerebral hemorrhage. Neurology. 2016 Jul 26;87(4):357-64.

A64. Altintas O, Tasal A, Niftaliyev E, Kucukdagli OT, Asil T. Association of platelet-to-lymphocyte ratio with silent brain infarcts in patients with paroxysmal atrial fibrillation. Neurol Res. 2016 Jul 21:1-6

A.65. Menon BK, Al-Ajlan FS, Najm M, Puig J, Castellanos M, Dowlatshahi D, Calleja A, Sohn SI, Ahn SH, Poppe A, Mikulik R, Asdaghi N, Field TS, Jin A, Asil T, Boulanger JM, Smith EE, Coutts SB, Barber PA, Bal S, Subramanian S, Mishra S, Trivedi A, Dey S, Eesa M, Sajobi T, Goyal M, Hill MD, Demchuk AM; INTERRSeCT Study Investigators. Association of Clinical, Imaging, and Thrombus Characteristics With Recanalization of Visible Intracranial Occlusion in Patients With Acute Ischemic Stroke. JAMA. 2018 Sep 11;320(10):1017-1026

A.68. Altintas O, Niftaliyev E, Asil T. The relationship between brain microbleeds and homeostatic markers in the treatment of ischemic stroke. Neurol Res. 2018 Dec;40(12):1048-1053.

A69. Menon BK, Al-Ajlan FS, Najm M, Puig J, Castellanos M, Dowlatshahi D, Calleja A, Sohn SI, Ahn SH, Poppe A, Mikulik R, Asdaghi N, Field TS, Jin A, Asil T, Boulanger JM, Smith EE, Coutts SB, Barber PA, Bal S, Subramanian S, Mishra S, Trivedi A, Dey S, Eesa M, Sajobi T, Goyal M, Hill MD, Demchuk AM; INTERRSeCT Study Investigators. Association of Clinical, Imaging, and Thrombus Characteristics With Recanalization of Visible Intracranial Occlusion in Patients With Acute Ischemic Stroke. JAMA. 2018 Sep 11;320(10):1017-1026.

A70. Yogendrakumar V, Al-Ajlan F, Najm M, Puig J, Calleja A, Sohn SI, Ahn SH, Mikulik R, Asdaghi N, Field TS, Jin A, Asil T, Boulanger JM, Hill MD, Demchuk AM, Menon BK, Dowlatshahi D; INTERRSeCT Investigators. Clot Burden Score and Early Ischemia Predict Intracranial Hemorrhage following Endovascular Therapy. AJNR Am J Neuroradiol. 2019 Apr;40(4):655-660

A71. Gensicke H, Evans JW, Al Ajlan FS, Dowlatshahi D, Najm M, Calleja AL, Puig J, Sohn SL, Ahn SH, Poppe AY, Mikulik R, Asdaghi N, Field TS, Jin A, Asil T, Boulanger JM, Hill MD, Goyal M, Demchuk AM, Menon BK; INTERRSeCT Investigators. Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort study. Neuroradiology. 2020 Mar;62(3):301-306.

A72. Kuang H, Qiu W, Najm M, Dowlatshahi D, Mikulik R, Poppe AY, Puig J, Castellanos M, Sohn SI, Ahn SH, Calleja A, Jin A, Asil T, Asdaghi N, Field TS, Coutts S, Hill MD, Demchuk AM, Goyal M, Menon BK; INTERRSeCT Collaborators. Validation of an automated ASPECTS method on non-contrast computed tomography scans of acute ischemic stroke patients. Int J Stroke. 2020 Jul;15(5):528-534.

 

A73. Cinar A, Cetin G, Altintas Kadirhan O, Turgut S, Ekinci I, Asil T. Determination of cerebral blood flow velocity and microembolic signals in essential thrombocytosis by transcranial doppler ultrasonography. Neurol Res. 2021 Feb;43(2):157-163

 

A74. Arslan GD, Olgun A, Ozcan D, Gökcal E, Guven D, Asil T. Assessment of Cerebral Vasomotor Reactivity in Patients With Primary Open-angle Glaucoma and Ocular Hypertension Using the Breath-Holding Index. J Glaucoma. 2021 Feb 1;30(2):157-163

 

A75. Ohara T, Menon BK, Al-Ajlan FS, Horn M, Najm M, Al-Sultan A, Puig J, Dowlatshahi D, Calleja Sanz AI, Sohn SI, Ahn SH, Poppe AY, Mikulik R, Asdaghi N, Field TS, Jin A, Asil T, Boulanger JM, Letteri F, Dey S, Evans JW, Goyal M, Hill MD, Almekhlafi M, Demchuk AM; for INTERRSeCT Study Investigators. Thrombus Migration and Fragmentation After Intravenous Alteplase Treatment: The INTERRSeCT Study. Stroke. 2021 Jan;52(1):203-212

 

A76. Milanlioglu A, Yaman A, Kolukisa M, Asil T. Evaluation of cerebral hemodynamic status in patients with unilateral symptomatic carotid artery stenosis during motor tasks, through use of transcranial Doppler sonography. Arq Neuropsiquiatr. 2022 Apr;80(4):339-343.

 

A77. Deniz C, Kula AY, Altunan B, Asil T. Effects of stroke etiology on angiographic success in patients undergoing mechanical thrombectomy.Neurol Sci. 2022 Jun;43(6):3737-3745.

A78. Çetinkaya E, Aralaşmak A, Goksungur G, Kaya MO, Toprak H, Kolukısa M, Asıl T, Kurtcan S, Özdemir H. Comparing Perfusion Data of CE-MRI, SWI and CTA with MR Perfusion in Stroke. Curr Med Imaging. 2022 Feb 11. doi: 10.2174/1573405618666220211092836.

A79. Sengeze N, Özdemir AÖ, Eren A, Aykac Ö, Sarıönder Gencer E, Giray S, Ali Yurekli V, Yıldırım S, Akpınar ÇK, Inanc Y, Acar BA, Baydemir R, Milanlioglu A, Cenikli U, Ozkul A, Gurkas E, Aytac E, Cabalar M, Gokce M, Bas DF, Asil T, Sair A, Karaibrahimoglu A. Predictors of Symptomatic Hemorrhage After Endovascular Treatment for Anterior Circulation Occlusions: Turkish Endovascular Stroke Registry. Angiology. 2022 Mar 6:33197221082711. doi: 10.1177/00033197221082711.

 

A80. Nasifov M, Ozmen E, Deniz C, Nadir A, Ozden O, Bingol G, Jafarov P, Asil T, Goktekin O, Sari I. Association of CHA2DS2-VASc score with successful recanalization in acute ischemic stroke patients undergoing endovascular thrombectomy. Postepy Kardiol Interwencyjnej 2022 Sep;18(3):269-275.  doi: 10.5114/aic.2022.122027.

 

A81. Kolukisa M, Koyuncu BA, Bayrakoglu A, Asil T. When Recurrent Strokes, Back Pain, and Alopecia Constitute a Hereditary Cause of Small-Vessel Disease, CARASIL in an Arabic Woman. Neurologist 2022 Dec 1.  doi: 10.1097/NRL.0000000000000476.